Alignment of alleles: Atlantic cod (Gadus morhua) IGHV1S2

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                 S   L   E   L   S   Q   P   V   A       V   V   V   R   T   T   E   P   L   V
  AJ279354,IGHV1S2*01, 34       AGC TTG GAA CTT TCC CAG CCT GTC GCT ... GTC GTT GTG AGA ACG ACA GAG CCA TTG GTC

                                                        ___________________CDR1-IMGT____________________
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                 L   T   C   K   V   T   G   Y   S   V   S   S   G   N   A   D   Y   A   T   G
  AJ279354,IGHV1S2*01, 34       CTT ACC TGT AAA GTA ACA GGA TAT TCT GTC AGT AGT GGT AAT GCA GAC TAC GCC ACA GGT

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60
                                 W   I   R   H   P   K   G   K   P   L   E   W   I   S   H   I   W   D   D   G
  AJ279354,IGHV1S2*01, 34       TGG ATC AGA CAT CCA AAA GGA AAA CCA CTG GAG TGG ATT TCC CAT ATC TGG GAC GAC GGA

                                IMGT________________
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                 D   I               F   K   N   N   A   L   S       N   K   F   T   I   S   R
  AJ279354,IGHV1S2*01, 34       GAT ATC ... ... ... TTT AAA AAC AAT GCG CTG TCT ... AAC AAG TTC ACA ATT TCT CGT


                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                 D   S   T   S   N   S   V   S   L   R   G   Q   N   L   Q   E   S   D   T   A
  AJ279354,IGHV1S2*01, 34       GAC TCG ACT AGT AAC TCA GTT TCT TTA AGA GGC CAG AAT TTG CAG GAG AGT GAT ACA GCT

                                                CDR3-IMGT
                                101 102 103 104 105 106
                                 V   Y   Y   C   A   R
  AJ279354,IGHV1S2*01, 34       GTG TAT TAC TGC GCC AGG    #c
#c: rearranged cDNA

This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.

Created: 21/01/2002
Author: Nathalie Bosc